Our mission is to elucidate the cellular and molecular mechanisms that establish and regulate the microtubule arrays of the neuron, during development, health, and disease.
The goals of our laboratory are to:
1. Elucidate the roles microtubule play in neuronal development, with emphasis on issues including axon development, dendrite development, growth cone turning, neuronal migration, and the branching of axons and dendrites.
2. Elucidate the cellular and molecular mechanisms by which the microtubule arrays of the neuron are established and regulated to carry out their various functional roles, with emphasis on microtubule-based molecular motor proteins and microtubule-severing proteins.
3. Elucidate the contribution of microtubule-based mechanisms to nerve degeneration that accompany disease and injury, with emphasis on spinal cord injury, Alzheimer’s disease, and Hereditary Spastic Paraplegia.
4. Develop novel microtubule-based therapies for treating injured or diseased axons.
Toward these ends, we use a variety of contemporary techniques, including microscopic, biochemical, and molecular assays.